Custom Chemical Synthesis - From Concept to Kilograms, faster.

Accelerate your molecule from idea to IND with Dalton’s end-to-end custom synthesis services.

Whether you need milligram discovery batches or multi-kilogram cGMP lots, our chemists, analysts, and project managers make scale-up smooth, compliant, and on budget.

Custom Chemical Synthesis has been a specialty since the inception of Dalton, and we are constantly advancing our capabilities and chemistry support services. Benefits for our clients include scalability, flexibility, speed, process control, quality and cost savings.

Why Top Biotech & Pharma Teams Choose Dalton

Your Challenge	Dalton Advantage
Hard-to-find or difficult-to-synthesize compounds	35+ years of complex small-molecule expertise—including building blocks, metabolites, excipients, APIs, drugs.
Scalability	Up to 200 L or 10kg scale up.
Full services	Custom synthesis, process development, Scale-up, R&D to GMP tech transfer, GMP manufacturing and testing.
Timelines & Quality	Dedicated project managers and Quality standards to keep your project on time and compliant.

Delivering Excellence in Custom Synthesis Solutions

Custom Synthesis: APIs, intermediates, excipients, metabolites, reference standards, impurities, isotope-labeled compounds, fluorescent probes, controlled substances (steroids, opioids, cannabinoids).
Process Development & Optimization: Route scouting, cost-reduction, yield improvement, impurity control.
Integrated Analytics: Full ICH-compliant method development, validation, and release testing performed in-house.
Regulatory Confidence: US FDA-inspected site, Health Canada DEL.

How it Works

Discovery Call
Align on chemistry scope, timelines, and success criteria.
Feasibility & Quote
Receive a fixed-price proposal with project milestones.
Design, Lab-Scale or Transfer
We develop or transfer the synthetic route.
Scale-Up & GMP Production
Seamless full scale tech transfer or scale-up to meet your needs.
Release & Documentation
Full CMC dossier support, stability data, and regulatory files.

We excel at process development, process improvement, tech transfers and scale-up. Dalton’s custom synthesis department is supported by our in-house analytical chemistry and microbiological laboratories offering full-service R&D and GMP testing.

Ready to Start?