Research & Development

Research & Development

Our R&D department plays a critical role in the life cycle of our products. Their focus includes the design, development and analysis of target molecules with the intent of scale-up processes to support manufacturing process development, process validation, and commercialization

We are always looking for new people to contribute to the company's growth. We offer a competitive salary and benefits and an excellent opportunity to build your career with a growing company. Thank you for your interest in working at Dalton Pharma. Please note that successful applicants will be notified by email within 2 weeks if they are selected for an interview. We do keep resumes on file. If we have an opening that better fits your career goals and experience, we will contact you.

Please forward your resume to:

Human Resources Department
Dalton Pharma Services Inc.
Email:

POSITIONS CURRENTLY AVAILABLE:


Analytical Chemist, Research and Development

We are seeking a skilled Analytical Chemist, with a.

In this position you will be responsible for development and validation of analytical test methods for the product development. Key duties include design, development and validation of new analytical methods, protocols and reports write-up, draft specifications and other documents for regulatory submissions. Testing of R&D batches, raw materials and packaging components in accordance with GMP/GLP regulations may be required as needed. Work should be completed with little supervision/guidance in a timely manner.

To qualify for this position, the candidate must possess the qualifications:

  • Complete all training assignments, SOPs and maintain personal training records
  • Develop and validate new analytical methods with minimum supervision
  • Execute and document all research work in accordance with current GMP/GLP regulations
  • Maintain a clean laboratory environment and ensure that safety regulations are followed
  • Interpret and compile analytical data, propose next steps on discussion with the Manager
  • Prepare protocols, development and validation reports
  • Participate in activities leading to product approval (i.e. deficiency letter responses for chemistry issues, investigations, etc., with specific tasks outlined by the Manager)
  • Provide technical support and coaching to other R&D Analytical Chemists
  • Participate in and/or lead for out-of-specs Investigations
  • Complete Corrective and Preventative Actions (CAPA’s)
  • Initiate and follow through with actions required to close Change Controls
  • Research and prepare specifications for product and packaging material
  • Attend project meetings and prepare project updates
  • Participate in Internal, Customer and Regulatory Audits

Knowledge, Skills and Abilities:

  • Superior theoretical and practical knowledge of organic, inorganic, physical and analytical chemistry including in-depth knowledge of gas and liquid chromatography, spectroscopy and other analytical techniques employed in the pharmaceutical development
  • Familiarity with modern computer assisted analytical instrumentation methods as well as with older techniques (i.e. titration)
  • Good understanding of GMPs and GLPs as well as with pertinent FDA and ICH guidelines
  • Ability to communicate and operate effectively in a team environment
  • Knowledge of applicable software
  • Good organizational and Multi-tasking skills. Detail-oriented. 
  • Excellent written and verbal communication skills.
  • Problem solving skills with significant degree of judgment based on prior experience, scientific knowledge and literature search. Problems include routine and non-routine tasks, such as chemistry related issues (i.e. understanding the degradation pathway of the active), instrumentation related problems (understanding symptoms of HPLC problems and eliminating/repairing them) and first review of out-of-spec investigations.

R&D CHEMISTRY MANAGER

Primary Responsibilities

  • Manage daily operations of R&D Chemistry team, including planning, scheduling and communicating project needs and updates internally and externally
  • Provide scientific guidance for a team of R&D chemists (10+) on research projects focusing on chemical synthesis and process development
  • Design and implement novel synthetic routes towards the synthesis of target molecules with efficient and economical manufacturing processes for scale-up from milligram scale syntheses to kilogram scale production
  • Carry out proposal evaluation, planning and costing
  • Provide technical guidance to Business Development/Customer service Teams, as well as other departments for resolving technical issues
  • Review research project proposals and reports
  • Managerial responsibilities of R&D department
  • Inter-departmental liaison to share project progress, timelines and technical expertise
  • Participate as SME for teleconferences with new and existing clients and provide technical guidance

Position Requirements

  • Ph.D. in Organic Chemistry or equivalent with 10+ years relevant experience or M.Sc. or equivalent with 15+ years relevant experience.
  • Extensive theoretical and practical knowledge for chemical synthesis, research and development, process development/optimization and scale-up.
  • Managerial experience in supervising a team of R&D Chemists for innovative research projects.
  • Strong analytical, problem-solving and decision making skills.
  • Active listener with effective verbal d written communication.
  • Demonstrated leadership and team building skills.

Working knowledge and experience with cGMP and CMC requirements


Senior Process Development Chemist

At Dalton, our people are our greatest strength, and our success has been built on our technical capabilities and the way we manage our relationships with each other. Our culture is supportive and innovative, driven by some of the Industry's best and brightest people helping us make the impossible possible, compliantly. Are you at the point in your career where you are looking for an environment where you’re inspired to explore your passions, where your talents are nurtured and cultivated? Do you strive to innovate with leading-edge scientific technologies? If so, join our team of innovative drug developers working together to bring innovative, life changing discoveries to the global market.

We are currently looking for dynamic and independent Senior Process Development Chemist within our research and development department.

Senior Process Development Chemist is responsible for the design, execution, scale-up, validation and tech transfer of new and current process systems to support manufacturing activities and to develop manufacturing processes for high volume and throughput. Ideal candidate will require 5-8 years of pharmaceutical/biotech engineering in the successful transfer of technology from R&D, Product/Process Development into Manufacturing and insure that standard operating procedures comply with cGMP, and other applicable requirements.

KNOWLEDGE AND SKILL REQUIREMENTS:

  • Excellent knowledge of cGMP and production requirements
  • Detail oriented and excellent organizational skills
  • Excellent oral and written communication skills

EDUCATION AND EXPERIENCE:

A minimum of a Bachelor’s degree in an engineering discipline Must have experience with production methods and manufacturing systems.

Must have at least five years’ experience in biotech or the pharmaceutical industry.

Must have at least two years of project management experience.


Synthetic Chemist

We are currently looking for dynamic and independent Synthetic Chemists within our research and development department. The preferred candidates will possess a minimum of a MSc. hands-on laboratory experience in synthetic chemistry within an industrial environment. S/he should possess superior skills in the interpretation of NMR, MS and HPLC. S/he must possess the ability to apply modern organic synthetic techniques, possess knowledge of typical modern purification methodologies and possess superior theoretical knowledge. S/he must have a proven track record of successfully completing challenging projects within tight deadlines. S/he must possess excellent communication skills both verbal and written and must be an excellent team player.


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